Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia
نویسندگان
چکیده
منابع مشابه
Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility.
OBJECTIVE Matrix metalloproteinase-2 (MMP-2) plays a major role in dysfunctional ventricular remodeling following myocardial injury induced by ischemia/reperfusion and heart failure. To directly assess the role of MMP-2 in the absence of superimposed injury, we generated cardiac-specific, constitutively active MMP-2 transgenic mice. METHODS Morphologic and functional studies were carried out ...
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Previous studies have yielded controversial results related to the contribution of matrix metalloproteinase-2 (MMP-2) -1306 C/T and -735 C/T polymorphisms in the progression of coronary artery disease (CAD). This study aimed to provide strong evidence for the role of the 2 polymorphisms in genetic risk of CAD.The human case-control studies regarding the association of MMP-2 polymorphisms with C...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2010
ISSN: 0959-9673
DOI: 10.1111/j.1365-2613.2010.00744.x